The method utilizes naltrexone, a non-addictive, opioid receptor antagonist medication. By taking naltrexone approximately one hour before drinking, individuals experience a diminished endorphin rush from alcohol consumption over time, leading to a gradual decrease in alcohol craving and intake. It is a unique approach that is transforming alcohol addiction treatment in Richmond, VA, and beyond. The Sinclair Method is a clinically tested approach where naltrexone is taken one hour before drinking. Over time, it helps your brain “unlearn” the connection between alcohol and pleasure, leading to reduced cravings and consumption. The Sinclair Method is the primary way for using naltrexone to treat Alcohol Use Disorder.
Addressing Common Concerns About TSM

Sinclair Method (TSM) is built around the principle of “pharmacological extinction,” which involves taking a specific medication, most commonly naltrexone, before drinking alcohol. The goal of TSM is not immediate abstinence but alcohol reduction by breaking the cycle of reward that sustains alcohol dependence. The Sinclair Method (TSM) is a groundbreaking approach to reducing alcohol dependency, using a scientifically backed process called pharmacological Sober living home extinction.
Regain Control of Your Drinking
- Positive TestimonialsMany TSM participants report a gradual but notable decline in alcohol consumption, sometimes achieving near-abstinence or drastically fewer binge episodes.
- Numerous individuals assert a significant improvement in their overall well-being, encompassing more than just their alcohol intake.
- You are encouraged to report negative side effects of drugs to the FDA.
The Sinclair method appeals to people who have struggled with relapse in abstinence-focused programs or who want a more flexible, personalized path to recovery. Food and Drug Administration (FDA) in 1984 for the treatment of opioid dependence. In 1994, based on emerging clinical evidence, it was also approved for the treatment of alcohol dependence.
What is Naltrexone?
The Thrive online alcohol addiction treatment program offers a science-backed, self-directed approach to reducing drinking from home. Approved by the FDA in 1994 for treating Alcohol Use Disorder (AUD), naltrexone works by binding to the brain’s opioid receptors, thereby blocking the release of endorphins triggered Sinclair method by alcohol consumption. In the context of TSM, the medication is not taken daily but rather is administered about one hour before the individual plans to drink alcohol.
How does TSM work?
Often, a provider will suggest self-directed modifications (such as “try to cut back”), or separate the substance use disorder from the rest of the healthcare plan entirely. The effects of the Sinclair Method may kick in within a few months to more than a year. This means you won’t feel the euphoric and sedative effects of opioids. But since naltrexone blocks alcohol’s pleasurable effects, the desire to drink decreases. This is because naltrexone won’t work if you take it during abstinence. In other words, it’s used to curb alcohol cravings, so the alcohol needs to be present.

How Can Patients Maximize Success with TSM?
The most common side effects involve increased nervousness, muscle or joint pain, headache, nausea, and upset stomach. In most cases, these side effects are mild and lessen with time as people become more accustomed to the medication or can be minimized by taking the medication with food. It needs to be used correctly and consistently in order for it to be effective.
How Does The Sinclair Method Differ from Traditional Abstinence-Based Approaches?
In his 2001 clinical studies, John Sinclair found that 78% of the individuals observed were able to reach extinction after several months. Patients who have done this therapy have reported only having one or two drinks at a time or event when they might usually drink much more, and it has helped them maintain longer periods of sobriety. Many people using naltrexone find that alcohol loses its appeal—not through sheer willpower, but through a gradual rewiring of the brain’s conditioned responses.
These elements help patients recover control over their alcohol consumption and enhance their well-being, therefore contributing to the general effectiveness of the treatment in this regard. Numerous individuals assert a significant improvement in their overall well-being, encompassing more than just their alcohol intake. One benefit of their drinking patterns is reducing negative effects, such as social problems or health concerns.